Possible? yea sure is Pete, I get days where I really don't want to turn the thing on but I guess I'm lucky that I don't really do any commercial cutting so the actual machine time isn't too bad.
The worst part for me is putting models together to test them,that can be fun on a new design but when your doing the same thing time and time again to work out a small detail it can get tedious.
Sometimes I like to run up a few giant scale models and other times making the same models scaled to 1mm mountboard is a giggle but the constant testing and looking for improvements on models is a pain.
One of the hardest designs has been the amity house, I must have cut 40 of those so far always looking for a tiny improvement or detail and while they are fun and a great item for commercial purposes ,looking at the same house for weeks at a time is mind numbing.
So "laser Fatigue"? yep, most certainly